Journal article
Metals and cholesterol: Two sides of the same coin in Alzheimer's disease pathology
BX Wong, YH Hung, AI Bush, JA Duce
Frontiers in Aging Neuroscience | FRONTIERS MEDIA SA | Published : 2014
Abstract
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of ß-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron, and zinc are abnormally accumulated and distributed in the aging brain. These metal ions can adversely contribute to the progression of AD. Dysregulation of cholesterol metabolism has also been implicated in the development of AD pathology. To date, large bodies of research have been carried out independently to elucidate the role of metals or cholesterol on AD pathology. Inter..
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Grants
Awarded by Alzheimers Research UK
Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council of Australia (to Ashley I. Bush and James A. Duce), Australian Research Council (to Ashley I. Bush), Cooperative Research Centre for Mental Health (to Ashley I. Bush), Alzheimer's Research UK (to James A. Duce), the Addi and Cassi Fund (to Ashley I. Bush and Ya Hui Hung), Perpetual Trustees [Harry Secomb Foundation and Payne L and Heather Medical Research Charitable Foundation (to Ashley I. Bush)], The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.